While levetiracetam was safe and well-tolerated, no between-group differences were observed for the total diazepam required and CIWA-Ar scores. Stock and colleagues completed a randomized, double-blind controlled study in an outpatient setting where gabapentin was compared with chlordiazepoxide in 26 veterans (25 males and one female) with mild-to-moderate AWS . There were no significant differences in AWS symptoms by medication; however, those in the gabapentin group reported decreased daytime sleepiness compared with those who received chlordiazepoxide. It is unclear if NBACs provide the same degree of protection from seizures and DTs and most studies are under-powered to detect differences in seizure and DT rates between groups.
- Some individuals have combined Keppra or other anticonvulsant medications with different medications to increase sedation.
- In summary, gabapentin may be an effective pharmacotherapy in the treatment of mild-to-moderate but not severe AWS symptoms.
- Additionally, alcohol metabolism in the body may affect the liver function and metabolism of Keppra.
- Learn about the dangers of mixing sleeping pills and alcohol, and what to do if you’ve already mixed them.
- Take this medicine only as directed by your doctor, to help your condition as much as possible.
The authors attempted to control for publication bias by also examining and reporting on current studies on clinicaltrials.gov. Future randomized controlled studies are needed to expand on the promising findings from the many open-label reports and to better understand the real-world efficacy of these pharmacotherapies. Higher valproate levels also conferred a greater advantage on drinking-related outcomes. Adjunctive divalproex did not improve bipolar disorder (both manic and/or depressive) symptoms ; however, this study was specifically powered for drinking-related measures. Most patients discontinued participation and, of those that completed therapy, divalproex was not superior to lithium alone on both mood and substance-related outcomes.
Mixing Keppra and Alcohol
While it’s generally not recommended to drink alcohol while taking Keppra, some people may be able to consume alcohol in moderation without experiencing significant side effects or reduced effectiveness of the medication. Medicines that interact with Keppra may either decrease its effect, affect how long it works, increase side effects, or have less of an effect when taken with Keppra. An interaction between two medications does not always mean that you must stop taking one of the medications; however, sometimes it does. Speak to your doctor about how drug interactions should be managed. Table 2 gives a summary of the findings for treating alcoholism with NBACs in terms of reducing harmful drinking patterns.
They may help patients who are attempting to stop drinking through suppression of the onset of symptoms of alcohol withdrawal. CIWA scores, for example, were low at the start of the study while many subjects were still actively drinking, and remained low, most likely as a result of treatment with levetiracetam. NBACs are unlikely to replace benzodiazepines for AWS, but may serve a helpful adjunct role, and may be useful as a monotherapy for milder sober living homes oxford houses cases with less risk of complications. Topiramate has proven efficacy in reducing the harmful drinking patterns of AUDs, suggesting it is on par with or perhaps superior to FDA-approved medications for the condition. In a two-center randomized placebo-controlled trial by Bonnet et al. , gabapentin was tested as an adjunctive medication to symptom-triggered clomethiazole for 61 inpatients with alcohol dependence and moderate-to-severe AWS.
If you notice any adverse effects, it may be best to limit or avoid alcohol altogether. Both alcohol and Keppra can affect liver function and metabolism. Alcohol is primarily metabolized in the liver, and excessive alcohol consumption can lead to liver damage and impairment. Keppra is also processed by the liver, and alcohol can potentially interfere with its metabolism, impacting its effectiveness. It’s crucial to be mindful of this potential interaction and prioritize liver health when consuming alcohol while on Keppra. Alcohol can increase the nervous system side effects of levETIRAcetam such as dizziness, drowsiness, and difficulty concentrating.
Short-Term and Long-Term Effects of Keppra Abuse
While in treatment, you will likely receive therapy, participate in support groups, learn about alcohol use disorder, and discover coping skills for relapse prevention. While Keppra doesn’t have much of a potential for abuse or dependency, alcohol does. There are many different types of treatment available for those struggling with alcohol use disorder and addiction. When Keppra is mixed with alcohol, it can make the medication less effective at treating seizure disorders. These types of medications also stop the release of calcium in the neurons which reduces their activity as well and makes many types of seizure disorders more manageable.
The impact of alcohol on Keppra can vary depending on individual factors such as dosage, frequency of alcohol consumption, overall health, and other medications being taken. It is always recommended to follow the guidance of a healthcare provider and discuss any concerns or questions regarding the use of alcohol while taking Keppra. The Epilepsy Community Forums are closed, and the information is archived. The content in this section may not be current or apply to all situations. In addition, forum questions and responses include information and content that has been generated by epilepsy community members. The information on these pages should not be substituted for medical advice from a healthcare provider.
Levetiracetam (Oral Route)
Levetiracetam has also been studied in three randomized controlled trials for the long-term treatment of AUD. Next, in a 42-day randomized, crossover, placebo-controlled trial in 46 non-treatment-seeking moderate-to-heavy drinkers, levetiracetam did not improve treatment outcomes relative to placebo . In fact, a median split into low- and high-level drinkers revealed that levetiracetam increased how to cure boredom alcohol consumption in the lower half relative to placebo. These results suggest that levetiracetam likely lacks efficacy in the treatment of alcohol dependence . A recent small placebo-controlled trial comparing the effects of topiramate, zonisamide, and levetiracetam showed a benefit of the medication on drinking outcomes versus placebo (described in more detail in Sect. 4.7) .
Mixing alcohol with Keppra can have various effects on the body and may impact the effectiveness of the medication. It’s essential to understand these risks to make informed decisions about alcohol consumption while on Keppra. Additionally, alcohol metabolism in the body may affect the liver function and metabolism of Keppra. Alcohol and Keppra are both metabolized in the liver, and excessive alcohol consumption can potentially impact the metabolism and elimination of Keppra from the body. This may result in altered drug levels and potentially reduce the effectiveness of Keppra in controlling seizures.
When people take prescription or over-the-counter medications, they should be aware if interactions with other drugs or substances — like alcohol — are possible. Drinking while taking Keppra can increase your risk of side effects and seizure threat if you drink heavily. Understanding that individuals may have varying responses to the combination of Keppra and alcohol is important. Some individuals may have a higher tolerance for alcohol and experience fewer side effects, while others may be more susceptible to adverse reactions. It is essential to be aware of your own body’s response and listen to any specific guidance provided by your healthcare provider.
The high-dose gabapentin group also reported better sleep, less daytime sedation, and better ability to work during follow-up than the lorazepam group. The results from the Minozzi et al.  review underscore the difficulty in developing and conducting well-designed studies to examine AWS. Before making any decisions about alcohol consumption while taking Keppra, it is crucial to consult with a healthcare professional. They can provide personalized advice based on your specific situation and medical history. They can also discuss any potential risks or interactions between Keppra and alcohol.
The general guidance for anticonvulsant medication tapering is one to three months. The physician decides how much to which mental disorder is most commonly comorbid with alcoholism lower the dose and at what frequency. Individuals should not try to taper themselves off of Keppra on their own.
Participating in Activities That Do Not Involve Alcohol
Understanding the DSM 5 classification of alcoholism can help you gain a better understanding of your situation and find the support you need. Alcohol also affects the body’s cardiovascular system by causing blood vessels to dilate, resulting in a drop in blood pressure. Measure the oral liquid with a marked measuring spoon, dropper, oral syringe, or medicine cup. The average household teaspoon may not hold the right amount of liquid. If you have any questions about this, ask your doctor or pharmacist.
Consumer Medicine Information
For individuals who find themselves struggling with addiction to alcohol while taking Keppra, it is important to seek the appropriate help and support. Recognizing the signs of addiction, reaching out for support, and exploring treatment options are crucial steps on the path to recovery. It’s important to note that everyone reacts differently to the interaction between keppra and alcohol.